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Mexico, Missouri is the county seat of Audrain County. The community was laid out at New Mexico in 1836, and was an important stop for settlers heading to the Republic of Texas, adopting its current name when it was named the county seat in 1837. Mexico was incorporated as a town in 1855. The Wabash Railroad came through in 1858, and the Alton Railroad in 1872, and the influx of businesses and people who came into the community after the railroad came through prompted its incorporation as a city in 1874. Mexico was within the blue grass region of Missouri, and was a shipping point for horses and mules, as well as a source of fire brick production, an industry that lasted until 2002, when both of its refractory plants closed. Christopher Samuel “Kit” Bond, former US senator and two-term governor of Missouri, grew up in Mexico and resided there as an adult, and Charles Henry Hardin, 22nd governor of Missouri, was residing in Mexico at the time of his death. Mexico is centered at the intersection of Missouri Routes 15 and 22, just west of US Highway 54 and the town of Vandiver, while Thompson is west of Mexico.

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