Immunophilins are members of a family of proteins which are cis-trans peptidyl-prolyl isomerases. Drugs acting on immunophilins include cyclosporine, sirolimus, and tacrolimus, all of which block T cell cytokine production by inhibiting activation of the NFAT transcription factor.
Recommended Resources
Allergy Cases: Drugs Acting on Immunophilins
Offers detailed information about immunophilins with sections on cyclosporine, tacrolimus, and sirolimus, diagrams of each, and how they are used as immunosuppressive drugs.
http://allergycases.org/2009/05/drugs-acting-on-immunophilins.html
Features a list of the brand names, both in the United States and in Canada, for cyclosporine, a description of its pharmacology and use in both the oral and the intravenous forms, pediatric and geriatric guidelines, drug interactions, and use by pregnant patients.
http://www.mayoclinic.com/health/drug-information/DR601591
The commercial site for Prograf, generically known as tacrolimus, provides data about both the capsules and injections, including indications, safety information, the history of the drug, and steps for long-term health.
http://www.prograf.com/
