Angiotensin II is a substance which is made by the body. It works on the cardiovascular system, narrowing the blood vessels which can lead to high blood pressure. It also releases a hormone which increases the amount of sodium in the body. ARBs block the receptor sites which allow them to work and help to relax the blood vessels.
Recommended Resources
Angiotensin-II Receptor Antagonists: Their Place in Therapy
American Family Physician offers this clinical pharmacology article regarding how these blockers are used in the pathophysiology of hypertension.
http://www.aafp.org/afp/990600ap/3140.html
NIH: Angiotensin II Receptor Blockers
The National Institutes of Health furnishes data about these agents including the pharmacology and special patient considerations.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1200815/
Texas Heart Institute: Angiotensin II Receptor Blockers
The famed cardiac hospital sets forth information about angiotensin II receptor blockers which includes the method in which they work, dosage details, and possible adverse effects.
http://www.texasheartinstitute.org/HIC/Topics/Meds/angimeds.cfm
