Alkylating antineoplastic agents is an alkylating agent for treatment of cancer. Before it was discovered that they worked in chemotherapy, alkylating agents were used in World War I as chemical weapons. They work by essentially attacking the DNA, which causes uncoiling and separation of the strands which keeps them from dividing.
Recommended Resources
Chemotherapy Drugs 101: Alkylating Antineoplastic Agents
Presents an overview of cyclophosphamide, mechlorethamine, chlorambucil, ifosfamide, camustine, streptozotocin, and uramustine.
http://www.lymphomainfo.net/blog/general-lymphoma-blogs/chemotherapy-drugs-101-alkylating-antineoplastic-agents
Nerdy Science: Alkylating Antineoplastic Agent
Addresses the history of chemotherapy, including how and why alkylating antineoplastic agents work.
http://science.kukuchew.com/tag/alkylating-antineoplastic-agent/
PharmaCorama: Alkylating Antineoplastic Agents
In-depth article about these agents includes an overview, information about N- chlorethylamine derivatives, and platinum complexes.
http://www.pharmacorama.com/en/Sections/Nucleic-acids-2.php
